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KMID : 1190620090050020079
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Journal of the Korean Wound Care Society
2009 Volume.5 No. 2 p.79 ~ p.87
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Salvianolic Acid A Inhibits Scar Formation by Interfering with the Activation of Macrophage and Fibroblast
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Kim Geun-Woong
Kim Do-Hoon
Sun Xiaoyan
Nhat Phan-Trong
Cho Kyung-Hwan
Yang Beom-Seok
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Abstract
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When Salvianolic acid A isolated from Danshen was applied for the full-excisional wound model in rabbit ear and rat dorsal skin, it showed a biological activity to diminish the scar formation. This activity was correlated with the suppression of macrophage activation. Salvianolic acid A treatment could suppress the stress-related signaling pathways in J774A.1 mouse macrophage cells which was activated by LPS. This suppression was correlated with the inhibition of inducible nitric oxide synthetase expression and focal adhesion kinase activation. In addition Salvianolic acid treatment inhibited the proliferation and migration of rat dermal fibroblast with the reduction of alpha smooth muscle actin expression. Taken together these data suggest that Salvianolic acid A can suppress the scar formation by interfering with the activating signaling pathways of dermal fibroblast and macrophage in wound healing process. (J Korean Wound Management Soc 2009;5:79-87)
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KEYWORD
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Salvianolic acid A, Scar, Dermal fibroblast, Macrophage
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